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Peptides  >  Enzyme Substrates and Inhibitors  >>  gp91 ds-tat

Product Name gp91 ds - tat
YGRKKRRQRRRCSTRIRRQL - NH2
Size 1 mg
Catalog # AS-63818
US$ $121
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into all cells. It is used as a peptide inhibitor for NADPH oxidase assembly.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Park, L. J. Neuroscience 25, 1769 (2005); Park, L. et al. Proc. Natl. Acad. Sci. 105, 1347 (2008)
Molecular Weight 2673.2
Sequence
(One-Letter Code)
YGRKKRRQRRRCSTRIRRQL-NH2
Sequence
(Three-Letter Code)
H - Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Cys - Ser - Thr - Arg - Ile - Arg - Arg - Gln - Leu - NH2
Product Citations He, Y. et al. (2011). Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate. ASN Neuro doi:10.1042/AN20100025.
Riquelme, D. et al. (2011). High-Frequency field stimulation of primary neurons enhances ryanodine receptor-mediated Ca2+ release and generates hydrogen peroxide, which jointly stimulate NF-kB activity. Antioxid Redox Signaling 14, 1245.
Xia, M. et al. (2009). Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2. JTH 8, 397.
     
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