This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261. Protein phosphorylation plays a key role in vasopressin signaling in renal-collecting duct. Phosphorylation at several AQP2 residues including Ser256 and Ser261, is altered in response to vasopressin. It is possible that both sites are involved in vasopressin-dependent AQP2 trafficking.
Nielsen, S. et al. PNAS 90, 11663 (1993); Hoffert, J. et al. PNAS 103, 7159 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Gln - Ser - Val - Glu - Leu - His - pSer - Pro - Gln - Ser - Leu - Pro - Arg - OH