Anionic interaction of Aß (1-11) with Factor XII is suspected to cause the massive activation of the C4 (Complement 4) system in cerebrospinal fluid of Alzheimer’s disease patients.
Ref: Chauhan, V. et al. J. Alzheimer’s Dis. 7, 37 (2005); Miller, D. et al. Biochem. 42, 11682 (2003); Bergamaschini, L. et al. Mech. Aging Dev. 122, 1971 (2001); Webster, S. et al. Am. J. Pathol. 150, 1531 (1997).
Molecular Weight
1325.3
Sequence (One-Letter Code)
DAEFRHDSGYE
Sequence (Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - OH
Material Safety Data Sheets (MSDS)
