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| Product Name |
[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27) |
| Size |
1 mg |
| Catalog # |
61937 |
| US$ |
$200 |
| Molecular Weight |
661.8 |
Sequence
(One-Letter Code) |
NF-(NMe-G)-A-(NMe-I)-L |
Sequence
(Three-Letter Code) |
H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH |
| Description |
This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis. |
| References |
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005). |
| Storage |
-20°C |
| Detailed Information |
 Material Safety Data Sheets (MSDS)
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