This peptide sequence comprises R9-Tat. R9-Tat is the arginine-substituted analog for the HIV Tat protein (48-60). Similar to Tat (48-60), R9-Tat is internalized by macrophages and translocated to the nucleus and cytoplasm. Additionally, R9-Tat is efficient in intracellular protein delivery, serving as a protein carrier for Carbonic anhydrase into the cell.
Futaki, S. et al. Advanced Drug Delivery Reviews57, 547 (2005).; Futaki, S. et al. J Biol Chem.276, 5836 (2001).; Futaki, S. et al. J Molec Recognition16, 260 (2003).
Molecular Weight
1803.1
Sequence (One-Letter Code)
GRRRRRRRRRPPQ
Sequence (Three-Letter Code)
H - Gly - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Pro - Pro - Gln - OH
Material Safety Data Sheets (MSDS)
