This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids.
Storage
-20°C
References
Lahdenranta, J. et al. FASEB J. 10.1096/fj.07-8273com (2007); Ellerby, H. et al. Nat. Med.5, 1032 (1999); Smolarczyk, R. et al. Acta Biochim. Pol.53, 801 (2006); Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem.13, 561 (2002).
H - Ala - Cys - Asp - Cys - Arg - Gly - Asp - Cys - Phe - Cys - Gly - Gly - D - Lys - D - Leu - D - Ala - D - Lys - D - Leu - D - Ala - D - Lys - D - Lys - D - Leu - D - Ala - D - Lys - D - Leu - D - Ala - D - Lys - NH2 (S - S bonded C1 - C4 & C2 - C3)
