This acetylated peptide is amino acids 2 to 28 N-terminus fragment of Annexin 1 (ANXA1). ANXA1, previously referred to as lipocortin 1 or LC1, is a member of the annexin superfamily that has potent leukocyte antimigratory activity. This fragment, as well as the full-length ANXA1, may significantly reduce polymorphonuclear leukocyte (PMN) influx in mice. ANXA1 and ANXA1 mimetics, such as Ac (2-12), inhibit recruitment of neutrophils in acute and chronic inflammation. This peptide is able to inhibit neutrophil extravasation.
Perretti, M. et al. Nat Med8, 1296 (2002); Mylinh, LA. et al. FASEB J15, 2247 (2001); Perretti, M. et al. Am J Pathol158, 1969 (2001); Lim, L. et al. Proc Natl Acad Sci USA 95, 14535 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ac - Ala - Met - Val - Ser - Glu - Phe - Leu - Lys - Gln - Ala - Trp - Ile - Glu - Asn - Glu - Glu - Gln - Glu - Tyr - Val - Val - Gln - Thr - Val - Lys - OH