This is EG3287, a peptide fragment based on the Neuropilin-1 (NRP-1) Vascular Endothelial Growth Factor A (VEGF-A) binding site, located on exons 7 and 8. EG3287 is a NRP-1 antagonist and contains an C-terminal Arg essential for inhibition of VEGF165 binding. As a result, EG3287 decreases tumor angiogenesis and growth.
Starzec, A. et al. Peptides28, 2397 (2007).
Sequence (One-Letter Code)
SCKNTDSRCKARQLELNERTCRCDKPRR (Disulfide bridge 2-20 and 9-22)
Sequence (Three-Letter Code)
H - Ser - Cys - Lys - Asn - Thr - Asp - Ser - Arg - Cys - Lys - Ala - Arg - Gln - Leu - Glu - Leu - Asn - Glu - Arg - Thr - Cys - Arg - Cys - Asp - Lys - Pro - Arg - Arg - OH (Disulfide bridge 2 - 20 and 9 - 22)