Posttranslational modifications (PTM) of histones, such as methylation, acetylation, and phosphorylation play a significant role in controlling gene expression and DNA repair. PTMs of histones have been correlated with a variety of human disease states including rheumatoid arthritis, cancer, heart disease, diabetes, neurodegenerative disorders. PTMs themselves are not sufficient to effect transcriptional activity, indicating the need for effectors proteins that bind modified residues and regulate nuclear function. These chromatin-associated proteins are gaining attention as potential therapeutic targets for epigenetic related diseases. Biotinylated histone peptides have been used to study effectors proteins translating PTMs into functional changes. The SensoLyte® Histone H3 (1-21) Sampler Kit provides 8 biotinylated H3 (1-21) derived histone peptides containing various PTM residues and control non-modified H3 (1-21) biotinylated peptide. These peptides can be utilized to design AlphaScreen® based methyltransferase/demethylase assays and for in vitro pull-down assays. All the components in this kit are also available as separate products and in bulk quantities.