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Peptides  >  Endothelins  >>  Endothelin 1, human, HiLyte™ Fluor 488-labeled

Product Name Endothelin 1, human, HiLyte™ Fluor 488 - labeled
HiLyte™ Fluor 488 - CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1 - 15 and 3 - 11)
Size 0.25 mg
Catalog # 64817-025
US$ $413
Purity % Peak Area By HPLC ≥ 95%
Description

This is a fluorescent (HiLyte™ Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20°C
References Yanagisawa, M. et al. Nature 332, 411 (1988).
Molecular Weight 2848.4
Sequence
(One-Letter Code)
HiLyte™ Fluor 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
Hilyte™ Fluor 488 - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide Bridge: 1 - 15 and 3 - 11)
     
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