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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Ac)4]-Histone H3 (1-21)-GGK(Biotin)

Product Name [Lys(Ac)4] - Histone H3 (1 - 21) - GGK(Biotin)
ART - K(Ac) - QTARKSTGGKAPRKQLAGG - K(biotin)
Size 0.25 mg
Catalog # 65207-025
US$ $115
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 with acetylation at Lys4. It is biotinylated through a C-terminal GGK linker. This post-translationally modified histone peptide is found in humans, Tetrahymena thermophila, Schizosaccharomyces pombe , and mice. Acetylation at Lys4 is controlled by Mst1. This peptide acts as a chromodomain switch by weakening the interaction between Chp1 and the H3K9 methylated tail, thus facilitating binding of HP1 proteins. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Xhemalce, B. and T Kouzarides. Gene Dev 24, 647 (2010); Garcia, B. et al. J Biol Chem 282, 7641 (2007).
Molecular Weight 2765.3
Sequence
(One-Letter Code)
ART-K(Ac)-QTARKSTGGKAPRKQLAGG-K(biotin)
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Lys(Ac) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(biotin) - OH
     
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