Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Histones  >  Histone H4 Peptides  >>  [Lys(Ac)12/16, Lys(Me1)20]-Histone H4 (1-25)-GSGSK(Biotin)

Product Name [Lys(Ac)12/16, Lys(Me1)20] - Histone H4 (1 - 25) - GSGSK(Biotin)
SGRGKGGKGLG - K(Ac) - GGA - K(Ac) - RHR - K(Me1) - VLRDNGSGS - K(Biotin)
Size 1 mg
Catalog # 65225-1
US$ $385
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H4 (1-25) with acetylation at Lys12 and Lys16 and monomethylation at Lys20, followed by a C-terminal GSGS linker and a biotinylated Lys. Monomethylation of histone H4 at Lys20 is associated with transcriptionally silent chromatin in higher eukaryotes. It has been shown that histone H4 is preferentially acetylated first at Lys16, then at Lys12. Diacetylated histone H4 has been shown to bind repressor protein TUP1. Acetylation of histone H4 also regulates heterochromatin formation by promoting the binding of bromodomains to p300 and transcription factor TAFII250 and inhibiting interactions with SIR3. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Rice, J. et al. Gene Dev 16, 2225 (2002); Sims, J. et al. J Biol Chem 281, 12760 (2006); Carmen, A. et al. J Biol Chem 277, 4778 (2002); Turner, B. et al. FEBS Lett 252, 141 (1989).
Molecular Weight 3330.8
Sequence
(One-Letter Code)
SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me1)-VLRDNGSGS-K(Biotin)
Sequence
(Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys(Me1) - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH
     
  < Back