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Perkin Elmer Storefronts  >  Histone H3 Peptides  >>  [Lys(Me2)36]-Histone H3 (21-44)-GK(Biotin), H3K36(Me2), biotin-labeled

Product Name [Lys(Me2)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me2), biotin - labeled
ATKAARKSAPATGGV - K(Me2) - KPHRYRPG - GK(Biotin)
Size 0.25 mg
Catalog # AS-64442-025
US$ $115
Purity % Peak Area By HPLC ≥ 95%
Description

This is a Histone 3 lysine 36 dimethylated peptide. This peptide has been shown to recruit histone deacetylase complex with nucleosomes and repress transcription. In addition, owing to its epigenetic repressive mark, it allows demethylation by a Jumonji C-domain family member, JMJD5 that functions as a transcription activator by inhibiting HDAC, and regulates cell cycle proliferation.

This peptide is Histone H3 amino acid residues 21 to 44 di-methylated at Lys-36 with an additional C-terminal glycine followed by a biotinylated lysine. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form

Storage -20C
References 1, Li B. et al. JBC. 284:7970-7976 (2009)
2, Hsia DA. et al. PNAS USA, 107(21):9671-9676 (2010).
Molecular Weight 2945.5
Sequence
(One-Letter Code)
ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Arg - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys(Me2) - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Gly - Lys(Biotin) - OH
Product Citations Adhikary, S. et al. (2015). Selective recognition of H3.1K36 dimethylation/H4K16 acetylation facilitates the regulation of all-trans-retinoic acid (ATRA)-responsive genes by putative chromatin reader ZMYND8 J. Biol. Chem. 291 2664-2681 doi: 10.1074/jbc.M115.679985
     
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