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Perkin Elmer Storefronts  >  Histone H3 Peptides  >>  [Lys(Me2)79]-Histone H3 (69 - 89), H3K79(Me2), amide

Product Name [Lys(Me2)79] - Histone H3 (69 - 89), H3K79(Me2), amide  NEW
Size 0.25 mg
Catalog # 65427-025
US$ $115
Description

H3K69 methylation is generally associated with transcriptional activation, with methylation catalyzed by DOT/DOT1L enzyme in the context of a nucleosome. Aberrant methylation of H3K79 has been implicated in leukemias. Histone H3 (69-89) peptides are used for assessing the specificity of anti-H3K79me antibodies.

Storage -20C
References Kouzarides, T. Curr Opin Genet Dev 12, 198 (2002). Ng, HH. et al. Genes Dev 16, 1518 (2002).
Sequence
(One-Letter Code)
RLVREIAQDF-K(Me2)-TDLRFQSSAV-NH2
Sequence
(Three-Letter Code)
H - Arg - Leu - Val - Arg - Glu - Ile - Ala - Gln - Asp - Phe - Lys(Me2) - Thr - Asp - Leu - Arg - Phe - Gln - Ser - Ser - Ala - Val - NH2
     
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