LyP-1 recognizes lymphatics and tumor cells in certain tumors, but not lymphatics in normal tissues. Screening on breast carcinoma xenografts shows positive to cyclic 9-amino-acid peptide, LyP-1. The LyP-1 also recognizes an osteosarcoma xenograft, and spontaneous prostate and breast cancers in transgenic mice. LyP-1 peptide is detected in tumor structures that are positive for several lymphatic endothelial markers and negative for blood vessel markers. LyP-1 accumulates in the nuclei of the putative lymphatic cells, and in the nuclei of tumor cells.
Zhang, L. et al. Canc. Res. 66, 5696 (2006); Akerman, M. et al. PNAS 99, 12617 (2002); Laakkonen, P.et al. Nat. Med. 8, 751 (2002).
Sequence (One-Letter Code)
CGNKRTRGC (S-S Bonded)
Sequence (Three-Letter Code)
H - Cys - Gly - Asn - Lys - Arg - Thr - Arg - Gly - Cys - OH (S - S Bonded)