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Peptides  >  Cyclic Peptides  >   Disulfide Cyclized Peptides  >>  Somatostatin 28, human, sheep, cow, rat, mouse, pig

Product Name Somatostatin 28, human, sheep, cow, rat, mouse, pig
SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: 17 - 28)
Size 0.5 mg
Catalog # AS-22901
US$ $110
Purity % Peak Area By HPLC ≥ 95%
Description

Somatostatin [SST, GHIH (growth hormone-inhibiting hormone) or SRIF (somatotropin release-inhibiting factor)] is a cyclic peptide existing in two isoforms and is produced in the pancreas islet, GI tract and the central nervous system. Tetradecapeptide Somatostatin-14 (SRIF-14, the originally identified somatostatin) and the 28-amino acid Somatostatin-28 (SRIF-28) have similar biological activities but differ in their potency. Somatostatins inhibit the release of growth hormone in contrast to Growth Hormone Factor (GRF), which stimulates the release of growth hormone. Somatostains also inhibit the release of prolactin and thyrotropin, peptide hormones from the pituitary gland and glucagon and insulin from the pancreas. It also controls the secretion of gut hormones and functions as a neurotransmitter.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Kim, D. et al. J Clin Endocrinol Metab 90, 6310 (2005)
Meyerhof, W. et al. Proc Natl Acad Sci USA 89, 10267 (1992)
Molecular Weight 3148.6
Sequence
(One-Letter Code)
SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: 17-28)
Sequence
(Three-Letter Code)
H - Ser - Ala - Asn - Ser - Asn - Pro - Ala - Met - Ala - Pro - Arg - Glu - Arg - Lys - Ala - Gly - Cys - Lys - Asn - Phe - Phe - Trp - Lys - Thr - Phe - Thr - Ser - Cys - OH (Disulfide bridge: 17 - 28)
Product Citations Zhao, X. et al. (2008). A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors. J Biomol Screen 13, 737.
     
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