Antimicrobial and Related Peptides

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Peptides > Antimicrobial and Related Peptides

Cationic antimicrobial peptides are important components of the innate defenses of all species. More than 100 of these peptides have been identified in numerous organisms, including fungi, insects, amphibians and humans. These hydrophobic and amphipathic peptides exhibit antibiotic, fungicidal, hemolytic, virucidal, and tumoricidal activities. Based on their structural properties, these antimicrobial peptides can be grouped into three classes, peptides that are helicoidal, peptides containing one to several disulfide bridges and peptides rich in certain amino acids such as proline or tryptophan. Most of these peptides share some common characteristics, such as their low molecular mass (2–5 kDa), the presence of multiple lysine and arginine residues and an amphipathic nature. Although the exact mechanism by which they kill bacteria is not clearly understood, it has been shown that peptide–lipid interactions leading to membrane permeation play a role in their activity. Examples of antibiotic peptides include magainins, secreted by the skin of Xenopus laevis; defensins from the human neutrophils and histatins from human saliva. Cecropins are produced by insects under conditions of infections. Cecropins A, B, and D are close homologues consisting of 35-39 residues found in the pupae of the cecropin moth.

Ref: Won, H. et al. Eur. J. Biochem. 269, 4367 (2002); Hancock, REW. and MG. Scott, Proc. Natl. Acad. Sci. USA 97, 8856 (2000); Andreu, D. et al. Proc. Natl. Acad. Sci. USA 80, 6475 (1983); M. Vaara and T. Vaara, Antimicrob. Agents Chemo. 38, 2498 (1994); Vizioli J. et al. Insect. Mol. Biol. 9, 75 (2000); Silvestro, L. et al. Antimicrob. Agents Chemo. 44, 602 (2000); Helmerhorst, E. et al. J. Biol. Chem. 274, 7286 (1999).

Product	Size	Catalog #	US$
5 - FAM - LC - LL - 37 5 - FAM - LC - LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTE S	0.1 mg	63694	$132

Ac - Lys(Ac) - D - Ala - D - Ala - OH Ac - Lys(Ac) - aa	50 mg	64561	$220

aKChaVAAWTLKAAa - Ahx - C aK - Cha - VAAWTLKAAa - Ahx - C	1 mg	24173	$143

aKChaVAAWTLKAAa - Ahx - C aK - Cha - VAAWTLKAAa - Ahx - C	5 mg	24174	$583

Apidaecin IB GNNRPVYIPQPRPPHPRL	1 mg	62044	$110

Aurein 1.1 GLFDIIKKIAESI - NH2	1 mg	62043	$83

Bac2A; Bactenecin 2A RLARIVVIRVAR - NH2	1 mg	64906	$71

Biotin - LC - LL - 37 Biotin - LC - LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRT ES	0.5 mg	63693	$291

CAP - 18, rabbit GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKLAPRTDY	0.5 mg	61307	$231

Cecropin A KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK - NH2	0.5 mg	24009	$176

Cecropin A KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK - NH2	1 mg	24010	$291

Cecropin B KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL - NH2	0.5 mg	24011	$176

Cecropin B KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL - NH2	1 mg	24012	$291

CSP - 2, Competence - Stimulating Peptide - 2 EMRISRIILDFLFLRKK	1 mg	63877	$105

Cys - LC - LL - 37 C - LC - LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	1 mg	63692	$291

Dermaseptin ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ	0.5 mg	61913-05	$242

Dermcidin, DCD - 1L SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLD SVL	0.1 mg	63713	$143

Drosocin GKPRPYSPRPTSHPRPIRV	1 mg	62600	$115

Elafin AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCC EGSCGMACFVPQ (Disufide bonds between Cys 16 - Cys45, Cys23 - Cys49, Cys32 - Cys44, Cys38 - Cys53)	0.1 mg	61641	$237

HEL (46 - 61) NTDGSTDYGILQINSR	1 mg	60504-1	$143

Histatin - 5 DSHAKRHHGYKRKFHEKHHSHRGY	1 mg	61001	$193

Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)] KFHEKHHSHRGY	1 mg	61002	$99

Human Lactotransferrin (37 - 61), Lactoferricin H TKCFQWQRNMRKVR - G - PPVSCIKRDS (Disulfide between Cys3 and Cys20)	1 mg	64074	$231

Human Platelet Factor IV 18, C18G ALYKKLLKKLLKSAKKLG	1 mg	62412	$110

Indolicidin ILPWKWPWWPWRR - NH2	1 mg	60999	$143

Innate Defense Regulator - 1 (IDR - 1) KSRIVPAIPVSLL	1 mg	62514	$83

KR - 12; LL - 37 (18 - 29) KRIVQRIKDFLR	1 mg	64812	$66

Lactoferricin B, Lactoferrin (17 - 41) FKCRRWQWRMKKLGAPSITCVRRAF (S - S BOND)	1 mg	62651	$198

LEAP - 1, Hepcidin, human DTHFPICIFCCGCCHRSKCGMCCKT (Disulfide bridges: 7 - 23, 10 - 13, 11 - 19, 14 - 22)	0.1 mg	61432	$215

LL - 37 fragment (18 - 37), LL - 18 - 37 KRIVQRIKDFLRNLVPRTES	1 mg	63712	$121

LL - 37 fragment (8 - 37), LL - 8 - 37 KSKEKIGKEFKRIVQRIKDFLRNLVPRTES	1 mg	63711	$242

LL - 37 pentamide LLGNFFRKSKQKIGKQFKRIVQRIKNFFRNLVPRTQS	0.5 mg	61309	$231

LL - 37, acetylated & amidated Ac - LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES - NH2	1 mg	63710	$303

LL - 37, Antimicrobial Peptide, human LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	1 mg	61302	$170

LL - 37, reverse sequence SETRPVLNRLFDKIRQVIRKFEKGIKEKSKRFFDGLL	0.5 mg	62208	$143

LL - 37, scrambled GLKLRFEFSKIKGEFLKTPEVRFRDIKLKDNRISVQR	1 mg	63708	$303

Magainin 1 GIGKFLHSAGKFGKAFVGEIMKS	0.5 mg	20791	$99

Magainin 1 GIGKFLHSAGKFGKAFVGEIMKS	1 mg	20792	$143

Magainin 2 GIGKFLHSAKKFGKAFVGEIMNS	0.5 mg	20639	$99

Magainin 2 GIGKFLHSAKKFGKAFVGEIMNS	1 mg	20640	$143

mCRAMP, mouse GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ	1 mg	61305	$275

Melittin, honey bee GIGAVLKVLTTGLPALISWIKRKRQQ - NH₂	1 mg	62366	$181

Mundticin KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK (Disulfide bridge: 9 - 14)	0.5 mg	61918	$445

NRC - 13 Pleurocidin GWRTLLKKAEVKTVGKLALKHYL - NH2	1 mg	64981	$171

OV - 1, sheep KNLRRIIRKIIHIIKKYG	1 mg	61310	$115

Protegrine - 1 (PG - 1), amide RGGRLCYCRRRFCVCVGR - NH2 (disulfide bridge:6 - 15 and 8 - 13)	1 mg	64819-1	$550

Protegrine - 1 (PG - 1), amide RGGRLCYCRRRFCVCVGR - NH2 (disulfide bridge:6 - 15 and 8 - 13)	0.5 mg	64819-05	$313

Pyrrhocoricin VDKGSYLPRPTPPRPIYNRN	1 mg	62601	$121

rCRAMP GLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ	0.5 mg	61306	$231

SMAP 29, Sheep Myeloid Antimicrobial Peptide 29 RGLRRLGRKIAHGVKKYGPTVLRIIRIAG	1 mg	61308	$231

Sub5 RRWKIVVIRWRR - NH2	1 mg	64962	$66

Temporin A, amide FLPLIGRVLSGIL - NH2	1 mg	64831	$83

Temporin L, amide FVQWFSKFLGRIL - NH2	1 mg	64836	$83

Ubiquitin (1 - 34) MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE	1 mg	62587	$297

Ubiquitin (65 - 76), (Ub2) STLHLVLRLRGG	1 mg	62586	$93

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