AnaSpec, EGT Group is pleased to provide a whole suite of reagents
for the advancement of Alzheimer’s disease (AD) research. From peptides to assay
kits to antibodies to dyes, AnaSpec is the trusted source of integrated proteomics
solutions for AD research. Amongst the more than 300 β-amyloid peptides, we
offer β-amyloid (1-40)
and (1-42) that are HFIP treated.
β-amyloids are amphiphilic peptides with a hydrophilic N-terminal domain
(residues 1 to 28) and a hydrophobic C-terminal (residues 29 to 40-42), the
latter corresponding to a part of the transmembrane domain of APP.1
β-Amyloid assembly into fibrils is initiated by a conformational transition
from random coil to β-sheet (hence the name β-amyloid) and a nucleation-dependent
aggregation process.1 Aβ peptides that are 39 to 42 amino acid
residues in length with a molecular mass of approximately 4 kDa are the core
components of neuritic plaques seen in Alzheimer’s disease (AD) brains. Studies
have found that dissolving in HFIP favors alpha helical structure and tends
to be monomeric.2 HFIP treatment of lyophilized Aβ-peptide results
in a dense, homogeneous preparation of unaggregated peptide and samples can
be stored as peptide films.3
Figure 1. A transmission electron
micrograph (TEM) image of fibrils from β-amyloid (1-42), HFIP treated peptide (Cat# 64129).
| Product |
Size |
Catalog # |
| Beta-Amyloid
(1-40) • HFIP
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
0.5 mg
1 mg |
64128-05
64128-1 |
| Beta-Amyloid
(1-42) • HFIP
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
0.5 mg
1 mg |
64129-05
64129-1 |
Related Products
Peptides
Beta-Amyloid
(1-28) and Related Peptides
Beta-Amyloid
(1-40) and Related Peptides
Beta-Amyloid
(1-42) and Related Peptides
Beta-Amyloid
(1-43) to (1-49) and (1-55) Peptides
Beta-Amyloid
Peptide Fragments
Beta-Amyloid
Peptides - Mouse/Rat
Amyloid
Toxicity Inhibitor Peptides
Amyloid
Precursor Protein (APP) / Amyloid Precursor-like Protein (APLP)
Collagen-like
Alzheimer Amyloid Plaque Component Precursor (CLAC-P)
Islet
Amyloid Polypeptides (IAPP)
Humanins
Other
Amyloid Related Peptides
Antibodies
Anti-β-Amyloid (1-40) &
(1-42) mAbs
Anti-Tau, phospho & non-phospho
Assay Kits
SensoLyte®
b-Amyloid (1-40) or (1-42) ELISA Assay Kits
SensoLyte®
a-Secretase (TACE) Assay Kits
SensoLyte®
Calpain Assay Kits
SensoLyte®
Cathepsin B Assay Kits
SensoLyte®
Cathepsin D Assay Kits
References
1. Jarrett, JT. et al. Biochem 32, 4693
(1993).
2. Barrow, CL. et al. J Mol Bio 225, 1075
(1992).
3. Stine, WB. et al. J. Biol. Chem., 278,
11612 (2003).
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