Custom Peptide


Since our inception in 1993, AnaSpec has assisted scientists in the design and synthesis of >50,000 peptides. As a result, our combined knowledge and expertise provide premium solutions to our customers.

AnaSpec's synthesis facilities located in Fremont, California means that we are able to provide comprehensive oversight of the entire peptide synthesis process. This ensures that we consistently meet our customer's product specifications. All custom peptides are accompanied with MS and HPLC analyses. Additional analytical data (e.g., amino acid analysis, sequencing) are available upon request. AnaSpec is also proud to be certified to ISO 9001:2008.

AnaSpec routinely completes difficult peptide synthesis such as synthesis of long peptides (>90-mers), peptides containing unusual modifications, and cyclic peptides. In addition, we have the capacity for large-scale synthesis (>100 g).

For additional information about our custom peptide synthesis services, please contact chemistry@anaspec.com

Request a free price quotation today

Custom Peptide Modifications

  • Alkyne peptides
  • FRETPeptide

  • Azide peptides
  • BSA, KLH conjugated peptides for antibody production
  • C-terminal modifications
    • Aldehydes
    • Alcohols
    • Chloromethyl Ketones
    • Cysteamide
    • Ester
    • N-Alkyl Amides
    • Hydrazides
    Figure 1. Schematic diagram of a hydrocarbon stapled peptide.
    • Thio ester
  • Cyclic peptides
  • Disulfide (S-S bond formation)
  • Dehydro peptides
    • dehydroalanine
    FRETPeptide
    • dehydroleucine
    • dehydroproline
  • Dityrosine Cross linked peptides
  • Drug-peptide conjugates
  • Dye-labeled peptides:
    • C-terminal
    • AFC, AMC, Dap(Dnp), Lys(Dye), pNA, Rh110
    • N-terminal
    • HiLyte™ Flour dyes (405, 488, 555, 647, 680, 750)
    Figure 2. Fluorescence is released when a protease recognizes and cleaves the FRET substrate.
    • QXL® quenchers
    • FAM, FITC, MCA, Rox, Sulforhodamine 101, TAMRA
  • FRET Substrates
  • biotinPeptide
    • 5-FAM/QXL® 520
    • HiLyte™ Fluor 488/QXL® 520
    • TAMRA/QXL® 570
    • EDANS/DABCYL & other FRET pairs
  • Glycopeptides
  • Heavy Isotope Labeled Peptides (ClearPoint peptides
    labeled with D, C13, N15)
  • Hydrocarbon Stapled Peptides
  • Lactam peptides
  • Lipopeptides
    • Prenylated
    Figure 3. The biotin end of the peptide is bound to streptavidin, and the other end is recognized by a target specific antibody.
    • Farnesyl
    • GeranylGeranyl
  • MAPS (Multiple Antigenic Peptide)
  • Methylated peptides
    • Lys(Me), Lys(Me)2, Lys(Me)3
      Arg(Me)2 symmetrical,
      Arg(Me)2 assymmetrical

    • Na-Methylated

    • Ca-Methylated
  • N-terminal Modifications
    • Acetylated
    • Biotinylated
    • Bromoacetylated
    • DOTA
    • Formylated
    • Myristoylated
    • Succinylated
  • Pegylated peptides
  • Peptide libraries
    • One-Bead One-Peptide
  • Peptidomimetics
  • Peptide bond modifications
    • Ester (Depsipeptides)
    • Amine (reduced amide bond)
  • Phosphopeptides
    • Phosphoserine, Phosphothreonine, Phosphotyrosine
  • Sulfated Tyrosine or Serine
  • Thiolactone peptide
  • TR-FRET Substrates
    • Europium/QXL® 610
    • Europium/HiLyte™ Fluor 647
  • Unusual Synthesis



















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