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| AnaSpec Introduces Suite of Rigorously Validated SOCS Antibodies |
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SOCS (suppressor of cytokine signaling), as the name implies, belong to a family of proteins that negatively regulates cytokine signaling.1 The structure of each member of the SOCS family consists of a central Src homology 2 (SH2) domain and a SOCS box motif of 40 amino acids on the C-terminus.2,3 The SOCS proteins form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism.4 Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
AnaSpec is pleased to introduce a suite of SOCS antibodies that have been validated in western blots (see Figure below) using cell or tissue lysates. These polyclonal antibodies, raised in rabbits and affinity purified, come in our new economical 50 µg format.
Related Products:
Primary and secondary (fluorescent and non-fluorescent) antibodies
Cell and tissue lysates
Custom monoclonal or polyclonal antibody services
References:
1. Krebs, DL and DJ. Hilton. J. Cell Sci. 113, 2813 (2000).
2. Starr, R. et al. Nature 387, 917 (1997).
3. Hilton, DJ. et al. Proc. Natl. Acad. Sci USA 95, 114 (1998).
4. Yoshimura, A. Cytokine Growth Factor Rev. 9, 197 (1998).
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