ClearPoint™ β-Amyloid Peptide Custom Synthesis


AnaSpec, the world’s largest provider of β-amyloid peptide and Alzheimer’s research reagents, also provides ClearPoint™ β-Amyloid custom peptide synthesis service. ClearPoint™ peptides are AnaSpec’s trademark collection of heavy or stable isotope labeled peptides and amino acids.

ClearPoint™ peptides offer a choice of heavy carbon (13C), or nitrogen (15N)-isotopes specifically labeled at single or universal positions. With over 10 years of successful synthesis, ClearPoint™ peptides are the proven solution for optimum quality heavy isotope labeled peptides.

These peptides can be used for the quantitative analyses of β-amyloid peptides in biological fluids using mass spectrometry (MS). The inclusion of internal heavy isotope labeled peptide standards makes mass spectrometry an absolute quantitation (AQUA) method for the peptide of interest.1

β-Amyloid (1-40) and (1-42) peptides have been used as biomarkers of Alzheimer's disease (AD). Historically, ELISA assays have been used in the quantitation of these peptides. However, technical challenges such as the tendency of β-amyloid (1-40) and (1-42) peptides to self-aggregate, undergo post-translational modifications or bind to other proteins often result in inaccuracies in quantitation when using ELISA.2 Oe, et al. reported the use of [15N]-labeled β-Amyloid peptides as internal standards using immunoaffinity purified CSF.2

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Below is a select listing of off-the-shelf GO® versions of our ClearPoint™ β-Amyloid peptides. For a full listing, please click here.

Product

Size

Catalog #

ClearPoint™ beta - Amyloid (1 - 15), 13C, 15N - Arg
DAEF - R* - HDSGYEVHHQ [R*=R(U - 13C6, U - 15N4)]

0.05 mg

64495

ClearPoint™ beta - Amyloid (1 - 40), 13C, 15N - Leu 17,34
DAEFRHDSGYEVHHQK - L* - VFFAEDVGSNKGAIIG - L* - MVGGV
V [L*=L(U - 13C6, U - 15N)]

0.05 mg

64493

ClearPoint™ beta - Amyloid (1 - 40), 13C, 15N - Val24, 13C - Ile31,32
DAEFRHDSGYEVHHQKLVFFAED - V* - GSNKGA - I* - I* - GLMVG
GVV [V*=V(U - 13C6, 15N)
& I*=I(U - 13C6)]

0.05 mg

64491

ClearPoint™ beta - Amyloid (1 - 42), 13C - Leu17,34
DAEFRHDSGYEVHHQK - L* - VFFAEDVGSNKGAIIG - L* - MVGGV
VIA [L*=L(U - 13C6)]

0.05 mg

64489

Related Products

Peptides
Beta-Amyloid (1-28) and Related Peptides
Beta-Amyloid (1-40) and Related Peptides
Beta-Amyloid (1-42) and Related Peptides
Beta-Amyloid (1-43) to (1-49) and (1-55) Peptides
Beta-Amyloid Peptide Fragments
Beta-Amyloid Peptides - Mouse/Rat
Amyloid Toxicity Inhibitor Peptides
Amyloid Precursor Protein (APP) / Amyloid Precursor-like Protein (APLP)
Collagen-like Alzheimer Amyloid Plaque Component Precursor (CLAC-P)
Islet Amyloid Polypeptides (IAPP)
Humanins
Other Amyloid Related Peptides

Antibodies
Anti-β-Amyloid (1-40) & (1-42) mAbs
Anti-Tau, phospho & non-phospho

Assay Kits
SensoLyte® Calpain Assay Kits
SensoLyte® Cathepsin B Assay Kits
SensoLyte® Cathepsin D Assay Kits

References

1. Harding, S. (ed.) 2007. Biotechnology & Genetic Engineering Reviews. Nottingham Univ. Press, Nottingham.
2. Oe, T. et al. Rapid Comm. Mass Spec. 20, 3723 (2006).