AnaSpec, the world’s largest provider of β-amyloid peptide
and Alzheimer’s research reagents, also provides ClearPoint™ β-Amyloid
custom peptide synthesis service. ClearPoint™ peptides are AnaSpec’s trademark
collection of heavy or stable isotope labeled peptides and amino acids.
ClearPoint™ peptides offer a choice of heavy carbon (13C),
or nitrogen (15N)-isotopes specifically labeled at single or universal
positions. With over 10 years of successful synthesis, ClearPoint™ peptides
are the proven solution for optimum quality heavy isotope labeled peptides.
These peptides can be used for the quantitative analyses of β-amyloid
peptides in biological fluids using mass spectrometry (MS). The inclusion of
internal heavy isotope labeled peptide standards makes mass spectrometry an
absolute quantitation (AQUA) method for the peptide of interest.1
β-Amyloid (1-40) and (1-42) peptides have been used as biomarkers
of Alzheimer's disease (AD). Historically, ELISA assays have been used in the
quantitation of these peptides. However, technical challenges such as the tendency
of β-amyloid (1-40) and (1-42) peptides to self-aggregate, undergo post-translational
modifications or bind to other proteins often result in inaccuracies in quantitation
when using ELISA.2 Oe, et al. reported the use of [15N]-labeled
β-Amyloid peptides as internal standards using immunoaffinity purified
CSF.2
To request a quotation, please click here or contact service@anaspec.com.
Below is a select listing of off-the-shelf GO® versions
of our ClearPoint™ β-Amyloid peptides. For a full listing, please click
here.
| Product |
Size |
Catalog # |
| ClearPoint™ beta
- Amyloid (1 - 15), 13C, 15N - Arg
DAEF - R* - HDSGYEVHHQ [R*=R(U - 13C6, U - 15N4)] |
0.05
mg |
64495 |
| ClearPoint™ beta
- Amyloid (1 - 40), 13C, 15N - Leu 17,34
DAEFRHDSGYEVHHQK - L* - VFFAEDVGSNKGAIIG - L* - MVGGV
V [L*=L(U - 13C6, U - 15N)] |
0.05 mg |
64493 |
| ClearPoint™ beta
- Amyloid (1 - 40), 13C, 15N - Val24, 13C
- Ile31,32
DAEFRHDSGYEVHHQKLVFFAED - V* - GSNKGA - I* - I* - GLMVG
GVV [V*=V(U - 13C6, 15N)
& I*=I(U - 13C6)] |
0.05 mg |
64491 |
| ClearPoint™ beta
- Amyloid (1 - 42), 13C - Leu17,34
DAEFRHDSGYEVHHQK - L* - VFFAEDVGSNKGAIIG - L* - MVGGV
VIA [L*=L(U - 13C6)] |
0.05 mg |
64489 |
Related
Products
Peptides
Beta-Amyloid (1-28) and Related Peptides
Beta-Amyloid (1-40) and Related Peptides
Beta-Amyloid (1-42) and Related Peptides
Beta-Amyloid (1-43) to (1-49) and (1-55) Peptides
Beta-Amyloid Peptide Fragments
Beta-Amyloid Peptides - Mouse/Rat
Amyloid Toxicity Inhibitor Peptides
Amyloid Precursor Protein (APP) / Amyloid Precursor-like Protein (APLP)
Collagen-like Alzheimer Amyloid Plaque Component Precursor (CLAC-P)
Islet Amyloid Polypeptides (IAPP)
Humanins
Other Amyloid Related Peptides
Antibodies
Anti-β-Amyloid (1-40) & (1-42) mAbs
Anti-Tau,
phospho & non-phospho
Assay Kits
SensoLyte®
Calpain Assay Kits
SensoLyte®
Cathepsin B Assay Kits
SensoLyte®
Cathepsin D Assay Kits
References
1. Harding, S. (ed.) 2007. Biotechnology & Genetic Engineering
Reviews. Nottingham Univ. Press, Nottingham.
2. Oe, T. et al. Rapid Comm. Mass Spec. 20, 3723 (2006).
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