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Peptides

(2S)-N-Fmoc-5-azido-pentanoic acid

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  • Cat.Number : AS-65518-1
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This unusual amino acid is used in Solid Phase Peptide Synthesis (SPPS) for the synthesis of modifiable side-chain peptides and proteins.1 The side-chain azido (N3) group is stable in trifluoroacetic acid (TFA) and piperidine (Pip), two reagents commonly used in SPPS. The azido group can be readily converted to an amine on the solid phase or in solution via Staudinger reduction.2 In addition, incorporation of azidohomoalanine into proteins has shown promise as an effective IR probe of local electrostatic environments in proteins.3

Specifications

Chemistry
CAS registry number
  • 1097192-04-5
Molecular Formula
  • C20H20N4O4
Molecular Mass/ Weight
  • 380.4
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Storage Conditions
  • -20°C
Activity
Usage
  • Research use

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References

β-Azidoalanine as an IR Probe: Application to Amyloid Aβ(16-22) Aggregation

J Phys Chem B . 2008 Aug 01 ; 112(33) 10352 | DOI : https://doi.org/10.1021/jp801558k

  • K. Oh
  • et al

Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

Org. Lett. . 2011 Sep 29 ; 13(20) 5440 | DOI : https://doi.org/10.1021/ol2020175

  • M.R.J. Vallee
  • et al