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Peptides

Azidohomoalanine - 100 mg

$655.00
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  • Cat.Number : AS-63669
  • Availability :
    In production

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An unusual amino acid used in Solid Phase Peptide Synthesis (SPPS) for the synthesis of modifiable side-chain peptides and proteins.1 The side-chain azido (N3) group is stable in trifluoroacetic acid (TFA) and piperidine (Pip), two reagents commonly used in SPPS. The azido group can be readily converted to an amine on the solid phase or in solution via the Staudinger reduction.2 In addition, incorporation of azidohomoalanine into proteins has shown promise as an effective IR probe into local electrostatic environments of proteins.3

Specifications

Chemistry
Molecular Formula
  • C4H8N4O2
Molecular Mass/ Weight
  • 144.1
Quantity & Purity
Purity
  • TLC major spot
Storage & stability
Storage Conditions
  • 4 °C
Activity
Usage
  • Research use

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Citations

A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.

J Neurosci . 2013 Feb 13 ; 33(7)3079 | DOI : 10.1523/JNEUROSCI.3430-12.2013

  • SP. Francis

Bio-inspired liposomal thrombomodulin conjugate through bio-orthogonal chemistry.

Bioconjugate Chem . 2013 Mar 15 ; 24(4)550 | DOI : 10.1021/bc300399f

  • H. Zhang

Combining pulsed SILAC labeling and click-chemistry for quantitative secretome analysis.

Methods Mol Biol.  . 2014 Jan 01 ; 1174 101 | DOI : 10.1007/978-1-4939-0944-5_7

  • K. Eichelbaum
  • J. Krijgsveld

Doxorubicin enhances nucleosome turnover around promoters.

Curr Biol. . 2013 Nov 06 ; 23(9)782 | DOI : 10.1016/j.cub.2013.03.043

  • F. Yang

Formation of Ubiquitin dimers via Azide–Alkyne click reaction.

Methods Mol Biol.  . 2012 Jan 11 ; 832 589 | DOI : 10.1007/978-1-61779-474-2_41

  • S. Eger

Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones.

Science . 2010 May 28 ; 328(5982)1161 | DOI : 10.1126/science.1186777

  • R. Deal

References

Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

Org. Lett. . 2011 Sep 29 ; 13(20) 5440 | DOI : https://doi.org/10.1021/ol2020175

  • M.R.J. Vallee
  • et al