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Labeling-detection

BSB [(trans,trans)-1-Bromo-2.5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene] - 5 mg

$184.00
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  • Cat.Number : AS-88300
  • Availability :
    In production

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BSB binds to a wide range of amyloid inclusions in situ. More importantly it is also used to label brain amyloids in live animals. BSB recognizes amyloid lesions, and has distinctive properties which allow the quantitative monitoring of the formation of amyloid fibrils assembled from the Ab peptide, a-synuclein and tau. It is a cell-permeable fluorescent probe that specifically binds to and labels intracellular b-amyloid aggregates both in vitro (Ki = 400 nM) and in vivo. It is also used as an antemortem diagnostic tool for animal models of Alzheimer’s disease.

Specifications

Chemistry
CAS registry number
  • 56776-28-4
Molecular Formula
  • C24H17BrO6
Molecular Mass/ Weight
  • 481.3
Properties
Absorbance (nm)
  • 340
Emission (nm)
  • 520
Color
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Resuspension condition
  • DMSO
Storage Conditions
  • -20°C Protected from Light
Activity
Application
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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References

A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114

J Neurochem . 2003 Sep 01 ; 86(6) 1359 | DOI : https://doi.org/10.1046/j.1471-4159.2003.01949.x

  • AS. Crystal
  • et al

Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in alzheimer’s disease

J Mol Neurosci . 2002 Aug 31 ; 19(1-2) 7 | DOI : 10.1007/s12031-002-0003-9

  • MP. Kung
  • et al