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Labeling-detection

Congo Red UltraPure Grade - 1 g

$158.00
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  • Cat.Number : AS-83016
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Early diagnosis and classification of amyloid deposition and differentiation from other glomerular fibrillar deposits rely on routine Congo red (CR) histochemistry. CR binding, monitored by characteristic yellow-green birefringence under crossed polarization has been used as a diagnostic test for the presence of amyloid in tissue sections for several decades. This assay is also widely used for the characterization of in vitro amyloid fibrils. CR is sandwiched between two protein molecules causing protein oligomerization. Congo red fluorescence (CRF) is an alternative method based on examination of the CR-stained section by ultraviolet (UV) light. Congo red fluorescence is simple to perform and more pronounced, therefore easier to evaluate than CR in bright light. Congo red, when combined with immunohistochemistry, is still visible under UV whereas CR is masked in bright light. Although not widely used, the CRF method for detecting amyloid is simple to use with a high specificity and sensitivity, and may be applied successfully to frozen sections.

Specifications

Chemistry
CAS registry number
  • 573-58-0
Molecular Formula
  • C32H22N6Na2O6S2
Molecular Mass/ Weight
  • 696.7
Properties
Absorbance (nm)
  • 497
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Resuspension condition
  • Water
Storage Conditions
  • -20°C Protected from Light
Activity
Application
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Congo Red-Positive Cardiac κ-AL Amyloidosis in Plasmacytoma – Case Report and Review of the Literature

Acta Med Austriaca . 2003 Feb 01 ; 30(1) 29 | DOI : https://doi.org/10.1046/j.1563-2571.2003.02051.x

  • A. Tzankov
  • et al

Is Congo red an amyloid-specific dye?

J Biol Chem . 2001 Jun 01 ; 276(25) 22715 | DOI : https://doi.org/10.1074/jbc.M011499200

  • R. Khurana
  • et al

Why Congo red binding is specific for amyloid proteins – model studies and a computer analysis approach

Med Sci Monit . 2001 Jul 08 ; 7(4) 771

  • I. Roterman
  • et al