EndoClear™ human recombinant a-Synuclein protein
- Cat.Number : AS-55555-100
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α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.
*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade.
alpha-synuclein protein available in the market.
The sequence (Accession # NP_000336) corresponding to the full-length human a-synuclein protein plus an affinity tag was expressed in E. coli. The recombinant a-synuclein protein was purified from bacterial lysate using a proprietary method, including tag cleavage. The resulting protein contains an additional Gly at the N-term of the a-synuclein sequence. The calculated molecular mass of the recombinant a-synuclein protein is ~14.5 kDa.
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References
Modulation of alpha-synuclein aggregation by dopamine analogs
PloS ONE . 2010 Feb 16 ; 5(2) e9234 | DOI : 10.1371/journal.pone.0009234
- D. Latawiec
- et al
Molecular determinants of the aggregation behavior of α- and β-synuclein
Protein Sci . 2008 May 01 ; 17(5) 887 | DOI : https://doi.org/10.1110/ps.073181508
- RC. Rivers
- et al
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary
Cancer . 2000 May 01 ; 88(9) 2154 | DOI : https://doi.org/10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9
- W. Bruening