α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.
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The sequence (Accession # NP_000336) corresponding to the full length human a-synuclein protein without affinity tag was expressed in E. coli. The recombinant a-synuclein protein was purified from bacterial lysate using proprietary method. The molecular mass of the recombinant a-synuclein protein is 14.5 kDa.