Peptides
Fmoc-Lys(N3)-OH
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- Cat.Number : AS-53100-F1
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An unusual amino acid used in Solid Phase Peptide Synthesis (SPPS) for the synthesis of side-chain modified peptides and proteins.1 The side-chain azido (N3) group is stable in trifluoroacetic acid (TFA) or piperidine (Pip), two reagents commonly used in SPPS. The azido group can be readily converted to an amine on the solid phase or in solution via the Staudinger reduction.2
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References
Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins
Org. Lett. . 2011 Sep 29 ; 13(20) 5440 | DOI : https://doi.org/10.1021/ol2020175
- M.R.J. Vallee
- et al