Protein

Human recombinant a-Synuclein (1-140), biotin labeled - 200 µg

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  • Cat.Number : AS-55581
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Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of α-synuclein is a critical step in the etiology of Parkinson's disease (PD). α-Synuclein is an abundant brain protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested for α-synuclein, and it also appears to be involved in vesicle release and trafficking. In vitro incubation in the presence of a specific amount of salt (i.e. 0.1M NaCl) with agitation shows α-synuclein forming fibrilous structure.

Recombinant human α-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with biotin.

Specifications

Chemistry
UniProt number
  • P37840
Molecular Mass/ Weight
  • 14.5 kDa
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Storage & stability
Form
  • In solution
Storage Buffer
  • 10 mM sodium phosphate buffer (pH=7.4)
Storage Conditions
  • Store at -80°C. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • human a-synuclein (1-140)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human

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References

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Science . 2000 Feb 18 ; 287(5456) 1265 | DOI : 10.1126/science.287.5456.1265

  • E. Masliah
  • et al

A Drosophila model of Parkinson's disease

Nature . 2000 Apr 23 ; 404(6776) 394 | DOI : 10.1038/35006074

  • MB. Feany
  • WW. Bender

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

Biochem . 1996 Oct 29 ; 35(43) 13709 | DOI : https://doi.org/10.1021/bi961799n

  • P.H. Weinreb
  • et al

Neuropathology in Mice Expressing Human α-Synuclein

J Neurosci . 2000 Aug 15 ; 20(16) 6021 | DOI : https://doi.org/10.1523/JNEUROSCI.20-16-06021.2000

  • H. van der Putten
  • et al

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses

Ann N. Y. Acad Sci . 2003 Jun 01 ; 991 107 | DOI : 10.1111/j.1749-6632.2003.tb07468.x

  • J. Trojanowski
  • VM. Lee