Human Sirtuin 2, recombinant
- Cat.Number : AS-72187
- Manufacturer Ref. :
-
Availability :
In stock
- Shipping conditions : Ice fees will apply
Alternative choices
Histone deacetylases (HDACs) act as transcriptional repressors of genes catalyzing the removal of acetyl groups from a ε-N-acetyl lysine of histone. Sirtuin 2 (SIRT2) belongs to a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases (class III HDACs) that target multiple protein substrates to execute diverse biological functions. Sirtuin 2 is the member of the family of Sir2 (Silent Information Regulator 2) proteins. Besides histones, substrates for SIRT2 also include various transcription factors, the tumor suppressor p53 and alpha-tubulin. Human SIRT2 is a cytoplasmic protein that increases in abundance during mitosis and regulates major events of cytokinesis.
The recombinant human Sirtuin 2 (GenBank Accession #: NM_030593) with 13-319 amino acids and His tag at its C-terminal was expressed in E. coli. The molecular mass of the enzyme is approximately 35.5 kDa on SDS-PAGE. Its activity can be measured using enzymatic assay with a fluorogenic or FRET substrate
Specifications
Chemistry | |
UniProt number |
|
---|---|
Molecular Mass/ Weight |
|
Modification | |
Conjugation |
|
Quantity & Purity | |
Concentration |
|
Purity |
|
Storage & stability | |
Form |
|
Storage Buffer |
|
Storage Conditions |
|
Activity | |
Application | |
Biomarker Target | |
Unit definition |
|
Specificity |
|
Research Area | |
Sub-category Research Area | |
Usage |
|
Source | |
Host | |
Source / Species |
|