NeoAntigens

As a result of high-rate tumor mutations, neoantigens are formed, which correspond to altered tumor protein sequences that have not yet been recognized by the immune system.

Since these mutations are absent from the normal human genome, the resultant tumor-specific neoantigens (TSNA) can be used as unique identifiers or markers of a specific tumor and pose exciting opportunities in immuno-oncology and vaccine therapies.

The neoantigen strategy may also apply to other diseases which rely on personalized medicines.

Learn more


White paper

Read AnaSpec's white paper “Neoantigens and their Applications”, to learn even more about the role of neoantigens in personalized immunotherapy.

 

GMP-grade peptides make a perfect fit as calibration standards for LC-MS/MS and 2D electrophoresis, for analyzing performance of mass spectrometers, and for characterizing proteins including their enzymatic activity.

 

 

Diagnostic testing

IVD companies or Clinical laboratories pursuing the development of in vitro diagnostic tests for the detection of molecules and analytes in biological samples, should consider using GMP grade peptide ASR’s.

GMP peptides can be used in in vivo diagnostic applications such as PET scan. Peptides used for in vivo diagnostic imaging are typically modified to improve their biological half-life, and to accommodate downstream radiolabeling. AnaSpec is specialized in both types of custom modifications to improve peptide metabolic stability, including cyclizations, incorporation of D-amino acids, PEGylations, and peptide conjugations to chelators such as DOTA for downstream radiolabeling.

*AnaSpec does not offer radiolabeling services

 

Pre-clinical animal testing

To facilitate consistency in pharmacokinetic and toxicity studies, GMP grade peptides should be considered for utilization in pre-clinical animal studies.

 

Skin cosmetics

Peptides are now regularly used in the cosmetics and anti-ageing market.

The skin care market is projected to increase over the next few years owed to the demand for new options in skin care cosmetics to improve skin tone, fine lines and wrinkles, texture, and hyperpigmentation, in a non-invasive manner.

Peptides will remain a key ingredient in cosmeceutical products, as their roles in collagen production and in skin protection (skin antimicrobial peptides), are further studied.  We expect to see such knowledge applied to the development of new skin care maintenance and repair alternatives.

 

Biomaterial Peptide Coatings

A major issue with implanted medical devices is the occurrence of biomaterial-associated infections (BAI).  These infections develop when microbial biofilms form on a device surface. As conventional antibiotic treatments cannot be localized onto a device, they are not an effective solution.  A potential answer is the application of GMP antimicrobial peptide coatings onto the medical device surface in order to target their effects.

 

BioPharmaceutical API precursors

GMP peptides synthesized at AnaSpec can be incorporated as starting materials or critical raw materials in the production of biopharmaceutical APIs.

One example is the conjugation of peptide antigen to sepharose beads to act as the ligand for the purification of a specific antibody Fab fragment.

Other examples are peptides conjugated to drugs for targeted delivery.

Do you need a solid partner for your GMP Peptide project?

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