OVA - a model antigen for immunology
Ovalbumin (OVA) is the main glycoprotein found in the egg white used extensively as a carrier protein/model antigen for immunology research.
OVA is a T-cell dependent antigen commonly used for studying antigen-specific immune responses in mice. Further, immune response to OVA is one of the best characterized in mice wherein immunodominant peptides that elicit T Cell responses have been identified.
Recently, dyes/small molecules labeled to OVA (eg. biotin or fluorescent dyes) have complemented well with the OVA immune-molecule portfolio as OVA conjugates thereby supporting many assays such as immune complex recycling, antigen-uptakes etc. Serving also as protein analysis and cellular tracking markers, OVA-fluorescent dye conjugates such as with HiLyte™ 488/555/647 are being used in lymphatic circulation tracking and drug delivery studies.
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