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Assay Kits  >  Coagulation Assay Kits  >>  SensoLyte ® Rh110 Factor Xa Assay Kit *Fluorimetric*

Product Name SensoLyte ® Rh110 Factor Xa Assay Kit *Fluorimetric*
Size 1 kit
Catalog # AS-72207
US$ $457

Factor Xa (FXa) is a serine endopeptidase composed of two disulfide-linked subunits. FXa leads to blood clot formation by converting prothrombin to thrombin through the prothrombinase complex. FXa is generated from zymogen Factor X via the intrinsic and extrinsic pathways and is the rate-limiting step in the propagation of thrombin generation. In the presence of Ca2+ ions, FXa forms prothrombinase with factor Va on the phospholipid membrane of the activated platelets. FXa has emerged as an attractive target for drug discovery for thromboembolic diseases.

The SensoLyteŽ Rh110 Factor Xa Assay Kit provides a convenient assay for screening of FXa inhibitors or continuous assay of enzyme activity using a fluorogenic substrate. Upon FXa protease cleavage, this substrate generates the Rh110 (rhodamine 110) fluorophore which has a bright green fluorescence that can be detected at excitation/emission=490 nm/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from other reaction components.

Kit size: 100 assays

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Product Citations Lagos, F. C. et al. (2017). Novel FXa Inhibitor Identification through Integration of Ligand- and Structure-Based Approaches molecules 22 1588, doi:10.3390/molecules22101588
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