EndoClearᵀᴹ * Human Recombinant alpha - Synuclein Protein less than 0.1 EU per μg protein
Greater than 95% as determined by SDS-PAGE.
Full-length Recombinant human alpha-synuclein (GenBank Accession # NP_000336) was expressed in E. coli., and purified from bacterial lysate using proprietary method. Endotoxin was further removed by proprietary technique. Molecular weight of the recombinant α-synuclein protein is 14.5 kDa.
α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.
EndoClearTM human α-synuclein recombinant protein (<0.1EU/ug protein) is available in various sizes: AS-55555-100, AS-55555-500, AS-55555-1000. For even lower endotoxin requirements, we offer EndoClearTMPlus (<0.001EU/ug protein) AS-56081-100 and AS-56081-500 * previously referred to as: EndoFree human α-synuclein recombinant protein
The purified α-synuclein is supplied as lyophilized powder nearly salt free. Store at 2-4 ºC for immediate use within 1-2 weeks or at –80 ºC for up to 12 months.
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