Assay Kits

Epigenetics

 

Sirtuin activity measurement

Our SensoLyte® Assay Kit provides a convenient, two-step homogeneous procedure for measuring sirtuin activity using a FRET or a fluorogenic substrate.

 

Role of Sirtuins

Histone deacetylases (HDAC) act as transcriptional gene repressor through the deacetylation of lysine residues on histone proteins. They are counter-balanced by Histone acetyltransferases (HATs).

Sirtuins (SIRTs) 1 and 2 are signaling proteins possess a deacetylase activity (class III HDACs) that require NAD+ as a cofactor. 

Sirtuin 1 (SIRT1) is involved in the regulation of tumor suppressor p53 through deactylation, thereby  inhibiting apoptosis. It also represents a target for treatment of age-related diseases and type II diabetes.

Sirtuin 2 (SIRT2) is a cytoplasmic protein involved in regulation of cell cycle, DNA repair and tumorogenesis.

  • Catalog Peptides

    We offer a large variety of modified histone peptide fragments

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  • Recombinant Proteins

    Check out our recombinant Sirtuin proteins

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