Epigenetics Recombinant Proteins

Role of Sirtuins

Histone deacetylases (HDAC) act as transcriptional gene repressors through the deacetylation of lysine residues on histone proteins. They oppose the effect of Histone methyltransferases.

Sirtuins (SIRTs) 1 and 2 are signaling proteins which possess a deacetylase activity (class III HDACs) that require NAD+ as a cofactor.

Sirtuin 1 (SIRT1) is involved in the regulation of tumor suppressor p53 through deactylation, thereby inhibiting apoptosis. It also represents a target for treatment of age-related diseases and type II diabetes.

Sirtuin 2 (SIRT2) is a cytoplasmic protein involved in regulation of cell cycle, DNA repair and tumorogenesis.