Peptides

390 MMP FRET Substrate 5 - 1 mg

$110.00
Check your price
  • Cat.Number : AS-62027
  • Availability :
    In stock

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a substrate for the MMP-12, macrophage elastase, Abs/Em = 325/393 nm. MMPs are considered to be critical mediators of both normal and pathological tissue remodeling processes.

Specifications

Chemistry
Sequence one letter code
  • Mca-PLGLEEA-Dap(Dnp)-NH2
Sequence three letter code
  • Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2
CAS registry number
  • 891198-38-2
Molecular Formula
  • C53H70N12O20
Molecular Mass/ Weight
  • 1195.2
Properties
Absorbance (nm)
  • 325
Emission (nm)
  • 393
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

You may also be interested in the following product(s)

IMG-EN-AS-55576-1-01.jpg

MMP-9 (Catalytic Domain), human recombinant

Cat.Number : AS-55576-1
$119.00 Excl. Tax
IMG-EN-AS-71158-01.jpg

SensoLyte® 520 Generic MMP Activity Kit Fluorimetric - 1 kit

Cat.Number : AS-71158
$554.00 Excl. Tax

References

Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12

JBC . 2006 Feb 15 ; 281 11152 | DOI : 10.1074/jbc.M600222200

  • L. Devel
  • et al