390 MMP FRET Substrate 5 - 1 mg
- Cat.Number : AS-62027
- Manufacturer Ref. :
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a substrate for the MMP-12, macrophage elastase, Abs/Em = 325/393 nm. MMPs are considered to be critical mediators of both normal and pathological tissue remodeling processes.
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References
Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12
JBC . 2006 Feb 15 ; 281 11152 | DOI : 10.1074/jbc.M600222200
- L. Devel
- et al