Peptides

390 MMP FRET Substrate XI - 5 mg

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  • Cat.Number : AS-27109
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This substrate is readily hydrolyzed by MMP-8, 9 and collagenase-3 (MMP-13), Abs/Em = 325/393 nm. The hydrolysis is inhibited in a 1:1 stoichiometric fashion by the tissue inhibitors of metalloproteinases, TIMP-1, TIMP-2, and TIMP-3.

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References

Kinetic Analysis of Matrix Metalloproteinase Activity Using Fluorogenic Triple-Helical Substrates

Biochem . 2001 Apr 18 ; 40(19) 5795 | DOI : https://doi.org/10.1021/bi0101190

  • JL. Lauer-Fields
  • et al

Biochemical characterization of human collagenase-3

J Biol Chem . 1996 Jan 19 ; 271(3) 1544 | DOI : 10.1074/jbc.271.3.1544.

  • V. Knauper
  • et al

Triple-helical peptide analysis of collagenolytic protease activity

Biol Chem . 2002 Jul 08 ; 383(7-8) 1095 | DOI : 10.1515/BC.2002.118.

  • JL. Lauer-Fields
  • GB. Fields