490 MMP FRET Substrate X - 1 mg
- Cat.Number : AS-27104
- Manufacturer Ref. :
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide has an optimized sequence for MMP-7, with the cleavage occuring at the Ala-Leu bond. The substrate is used for high throughput screening of MMP-7 inhibitors. Abs/Em = 340/490 nm.
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References
Flow injection analysis for measurement of activity of matrix metalloproteinase-7 (MMP-7)
J Pharm Biomed Anal . 1997 Jun 01 ; 15(9-10) 1417 | DOI : https://doi.org/10.1016/S0731-7085(97)00035-6
- M. Itoh
- et al
Purification of Human Matrilysin Produced inEscherichia coliand Characterization Using a New Optimized Fluorogenic Peptide Substrate
Arch Biochem Biophys . 1995 Dec 01 ; 324(1) 59 | DOI : https://doi.org/10.1006/abbi.1995.9929
- AR. Welch
- et al