Peptides

Caspase 1 (ICE) Inhibitor II - 1 mg

  • Cat.Number : AS-60840
  • Availability :
    In production

Select specification

Quantity

Caspase 1 Inhibitor II is an irreversible caspase-1, (IL-1β-converting enzyme, ICE) inhibitor. It is neuroprotective, rescuing neuronal cell cultures from cell death. It alco reduces lipopolysaccharide-lethality in animals.

Specifications

Chemistry
Sequence one letter code
  • Ac-YVAD-CMK
Sequence three letter code
  • Ac-Tyr-Val-Ala-Asp-Chloromethyl Ketone
CAS registry number
  • 178603-78-6
Molecular Formula
  • C24H33ClN4O8
Molecular Mass/ Weight
  • 541
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in rat organotypic hippocampal slices

Brain Res . 2000 Jun 01 ; 867(1-2) 62 | DOI : https://doi.org/10.1016/S0006-8993(00)02230-7

  • A. Ray
  • et al

Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses

Br J Pharmacol . 2000 Oct 01 ; 131(3) 383 | DOI : https://doi.org/10.1038/sj.bjp.0703629

  • G. Mathiak
  • et al

Evidence That Inhibition of Cathepsin-B Contributes to the Neuroprotective Properties of Caspase Inhibitor Tyr-Val-Ala-Asp-Chloromethyl Ketone

J Biol Chem . 2001 Aug 01 ; 276(35) 32750 | DOI : https://doi.org/10.1074/jbc.M103150200

  • J. Gray
  • et al