Peptides

Histone deacetylase, HDAC substrate - 1 mg

$154.00
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  • Cat.Number : AS-61855
  • Availability :
    In production

Quantity

This novel fluorogenic substrate of HDACs was synthesized with an epsilon-acetylated lysyl moiety and an adjacent MCA moiety at the C-terminus of the peptide chain. The assay utilizing this substrate provides a good tool to characterize the HDAC activity. HDACs are important enzymes for the transcriptional regulation of gene expression.

Specifications

Chemistry
Sequence one letter code
  • Ac-RGK(Ac)-AMC
Sequence three letter code
  • Ac-Arg-Gly-Lys(Ac)-AMC
CAS registry number
  • 660846-97-9
Molecular Formula
  • C28H40N8O7
Molecular Mass/ Weight
  • 600.7
Properties
Absorbance (nm)
  • 354
Emission (nm)
  • 442
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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References

A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening

Chem Biol . 2003 Jan 01 ; 10(1) 61 | DOI : https://doi.org/10.1016/S1074-5521(02)00305-8

  • D. Wegener
  • et al