IMG-EN-AS-55457-01.jpg
Protein

Human recombinant a-Synuclein (1-140), HiLyte™ Fluor 488 labeled - 200 µg

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  • Cat.Number : AS-55457
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Parkinson's disease (PD) is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of α-synuclein is a critical step in the etiology of PD. α-Synuclein is an abundant brain protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, among which are vesicle release and trafficking. In vitro incubation in the presence of salt (i.e. 0.1M NaCl) with agitation causes α-synuclein to form fibrils.

The recombinant human α-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte™ Fluor 488. Green fluorescence: Excitation/Emission wavelengths= 503 nm/525 nm

Specifications

Chemistry
UniProt number
  • P37840
Molecular Mass/ Weight
  • 14.5 kDa
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 525
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Storage & stability
Form
  • In solution
Storage Buffer
  • 10 mM sodium phosphate buffer (pH=7.0)
Storage Conditions
  • Store at -80°C. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Detection Method
Specificity
  • human a-synuclein (1-140)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human

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References

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Science . 2000 Feb 18 ; 287(5456) 1265 | DOI : 10.1126/science.287.5456.1265

  • E. Masliah
  • et al

A Drosophila model of Parkinson's disease

Nature . 2000 Apr 23 ; 404(6776) 394 | DOI : 10.1038/35006074

  • MB. Feany
  • WW. Bender

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

Biochem . 1996 Oct 29 ; 35(43) 13709 | DOI : https://doi.org/10.1021/bi961799n

  • P.H. Weinreb
  • et al

Neuropathology in Mice Expressing Human α-Synuclein

J Neurosci . 2000 Aug 15 ; 20(16) 6021 | DOI : https://doi.org/10.1523/JNEUROSCI.20-16-06021.2000

  • H. van der Putten
  • et al

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses

Ann N. Y. Acad Sci . 2003 Jun 01 ; 991 107 | DOI : 10.1111/j.1749-6632.2003.tb07468.x

  • J. Trojanowski
  • VM. Lee