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Peptides

Keratin K18-C - 5 mg

$679.00
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  • Cat.Number : AS-60214-5
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This peptide corresponds to human keratin K18 amino acids 26-38, with an additional C-terminal cysteine. The sequence is identical to mouse K18 except that human K18 Val28 is replaced by alanine in the mouse sequence. Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in-vivo, in a cell-cycle- and phosphorylation-dependent manner. K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins and plays a role in keratin organization and distribution.

Specifications

Chemistry
Sequence one letter code
  • RPVSSAApSVYAGAC
Sequence three letter code
  • H-Arg-Pro-Val-Ser-Ser-Ala-Ala-pSer-Val-Tyr-Ala-Gly-Ala-Cys-OH
Molecular Formula
  • C56H92N17O22PS
Molecular Mass/ Weight
  • 1418.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

Embo J . 1998 Apr 01 ; 17 1892 | DOI : https://doi.org/10.1093/emboj/17.7.1892

  • NO. Ku
  • et al