IMG-EN-AS-65452-1-01.jpg
Peptides

LL-37 fragment (17-32)

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  • Cat.Number : AS-65452-1
  • Availability :
    In production

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This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.

Specifications

Chemistry
Sequence one letter code
  • FKRIVQRIKDFLRNLV
Sequence three letter code
  • H-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-OH
Molecular Formula
  • C95H161N29O21
Molecular Mass/ Weight
  • 2045.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region

J Am Chem Soc . 2006 May 03 ; 128(17) 5776 | DOI : 10.1021/ja0584875

  • X. Li
  • et al

References

LL-37, the only human member of the cathelicidin family of antimicrobial peptides

Biochim Biophys Acta . 2006 Sep 01 ; 1758(9) 1408 | DOI : https://doi.org/10.1016/j.bbamem.2006.03.030

  • UHN. Dürr
  • et al

Reversal of ABCG2-mediated multidrug resistance by human cathelicidin and its analogs in cancer cells

Peptides . 2013 Feb 01 ; 40 13 | DOI : https://doi.org/10.1016/j.peptides.2012.12.019

  • KK. To
  • et al