Peptides

LL-37 fragment (18-37) - 1 mg

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  • Cat.Number : AS-63712
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This is fragment 18-37 of LL-37, it exhibits enhanced antimicrobial activity. Antimicrobial peptide LL-37, belonging to the cathelicidin family, is the first amphipathic alpha-helical peptide isolated from human. It plays an important role in the first line of defense (innate immunity) against local infection and systemic invasion of pathogens at sites of inflammation and wounds.

Specifications

Chemistry
Sequence one letter code
  • KRIVQRIKDFLRNLVPRTES
Sequence three letter code
  • Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
CAS registry number
  • 672333-78-7
Molecular Formula
  • C109H190N36O29
Molecular Mass/ Weight
  • 2469.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides.

Mol Microbiol . 2009 Aug 06 ; 73(5) 844 | DOI : 10.1111/j.1365-2958.2009.06801.x.

  • GE. Purdy
  • et al

Neutrophil extracellular Trap–associated protein activation of the NLRP3 inflammasome is lnhanced in lupus macrophages.

J Immunol . 2012 Dec 24 ; 190(3) 1217 | DOI : 10.4049/​jimmunol.1202388.

  • JM. Kahlenberg

Clostridium difficile clinical isolates exhibit variable susceptibility and proteome alterations upon exposure to mammalian cationic antimicrobial peptides.

Anaerobe . 2012 Sep 24 ; 18(6) 614 | DOI : 10.1074/jbc.M110.206110

  • R. McQuade
  • et al

Hormonally active vitamin D3 (1α,25-Dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.

JBC . 2011 Mar 30 ; 286(21) 18890 | DOI : 10.1074/jbc.M110.206110

  • GR. Campbell
  • SA. Spector