Renin FRET Substrate (5-FAM/QXL® 520) - 0.1 mg
- Cat.Number : AS-61872-01
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This FRET peptide is a specific substrate for renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening of renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. This substrate is employed in the SensoLyte® 520 Renin Assay Kit, cat # 72040.
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References
Effects of a specific and long-acting renin inhibitor in the marmoset.
Hypertens . 1985 Sep 01 ; 7(5) 797 | DOI : https://doi.org/10.1161/01.HYP.7.5.797
- J. Wood
- et al
The role of renin substrate in hypertension.
Hypertens . 1983 May 01 ; 5(3) 353 | DOI : https://doi.org/10.1161/01.HYP.5.3.353
- D. Gordon
Newly Recognized Components of the Renin-Angiotensin System: Potential Roles in Cardiovascular and Renal Regulation
Endocr Rev . 2003 Jun 01 ; 24(3) 261 | DOI : https://doi.org/10.1210/er.2003-0001
- R. Carey
- H. Siragy
Structure-based design of aliskiren, a novel orally effective renin inhibitor
Biochim. Biophys. Res. Com. . 2002 Sep 05 ; 308(4) 698 | DOI : https://doi.org/10.1016/S0006-291X(03)01451-7
- J. Wood
- et al