SensoLyte® 520 MMP-7 Assay Kit Fluorimetric - 1 kit
- Cat.Number : AS-71153
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MMP-7 (matrilysin, PUMP) is involved in biological events, such as tissue remodeling, cell proliferation and host defenses.
SensoLyte® 520 MMP-7 Assay Kit uses a 5-FAM (fluorophore) and QXL520™ (quencher) labeled FRET peptide substrates for continuous measurement of the enzyme activities. In an intact FRET peptide, the fluorescence of 5-FAM is quenched by QXL520™. Upon the cleavage of the FRET peptide by MMP-7, the fluorescence of 5-FAM is recovered, and can be continuously monitored at excitation/emission = 490 nm/520 nm. With superior fluorescence quantum yield and longer emission wavelength, 5-FAM/QXL520™ based FRET peptide is less interfered by the autofluorescence of test compounds and cellular components and provides better assay sensitivity.
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Citations
Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-β autocrine loop
Oncotarget. . 2016 Sep 27 ; 7(39) 63324 | DOI : 10.18632/oncotarget.11450
- Y. Zeng
- et al
Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease.
Sci Rep . 2021 Aug 23 ; 11 17071 | DOI : https://doi.org/10.1038/s41598-021-96554-7
- N-R. Im
- et al
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells.
Front Cell Dev Biol . 2020 Jul 09 ; 8 608 | DOI : https://doi.org/10.3389/fcell.2020.00608
- Y. Liu
- et al