ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R - 1 mg
- Cat.Number : AS-60431-1
- Manufacturer Ref. :
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Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage.
This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.
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Citations
Divergent pathways for the angiotensin-(1–12) metabolism in the rat circulation and kidney
Peptides. . 2012 Apr 03 ; 35(2) 190 | DOI : 10.1016/j.peptides.2012.03.025
- BM. Westwood
- MC. Chappell
The Design and Synthesis of Novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
Bioorg Med Chem Lett. . 2011 Jan 18 ; 21(5) 1376 | DOI : 10.1016/j.bmcl.2011.01.036
- C. Savi
References
Identification and Characterization of 4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a Novel Dual Tumor Necrosis Factor-α-Converting Enzyme/Matrix Metalloprotease Inhibitor for the Treatment of Rheumatoid Arthritis
J Pharmacol Exp Ther . 2004 Apr 01 ; 309(1) 348 | DOI : https://doi.org/10.1124/jpet.103.059675
- Y. Zhang
- et al