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Peptides

Tat-Beclin-1 scrambled - 1 mg

$251.00
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  • Cat.Number : AS-65468
  • Availability :
    In stock

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Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that may trigger cellular adaptation, survival or cell death. When conjugated to the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control.

Specifications

Chemistry
Sequence one letter code
  • YGRKKRRQRRRGGVGNDFFINHETTGFATEW
Sequence three letter code
  • Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Val-Gly-Asn-His-Phe-Phe-Ile-Asn-His-Ser-Thr-Thr-Gly-Phe-Ala-Thr-Gln-Trp-OH
Molecular Formula
  • C164H251N57O45
Molecular Mass/ Weight
  • 3741.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Identification of a candidate therapeutic autophagy-inducing peptide.

Nature . 2013 Jan 30 ; 494(7436) 201 | DOI : 10.1038/nature11866

  • S. Shoji-Kawata
  • et al

Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch

Am J Cancer Res . 2012 Feb 15 ; 2(2) 214 | DOI : PMID: 22485198

  • RT. Marquez
  • et al