This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524–543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.
Quinn, A. et al. J. Immunol.166, 2982 (2001); Dai, Y. et al. J. Immunol. 175, 3621 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Arg - Leu - Ser - Lys - Val - Ala - Pro - Val - Ile - Lys - Ala - Arg - Met - Met - Glu - Tyr - Gly - Thr - Thr - OH