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Peptides  >  HIV Related Peptides  >>  HIV Substrate, HiLyteᵀᴹ Fluor 488

Product Name HIV Substrate, HiLyteᵀᴹ Fluor 488
QXL® 520 - GABA - SQNYPIVQ - K(HiLyte™ Fluor 488) - NH2
Size 0.1 mg
Catalog # AS-60635
US$ $115
Purity % Peak Area By HPLC ≥ 95%

Ths is a HiLyte Fluor labeled HIV protease substrate I, GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS. The peptide sequence is derived from the native p17/p24 cleavage site on HIV precursor polyprotein Prgag for HIV-1 protease. Cleavage of HIV precursor polyproteins is essential for the maturation of the infectious virus and hence the protease has become a major target for developing anti-AIDS drugs. The peptide substrate is widely used for the continuous assay for HIV protease activity. The QXL/488 pair offers better sensitivity in detection at a higher wavelength with less background interference. (Excitation/Emission = 490 nm/520 nm).

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20°C
References 1, Seelmeier S, et al. Proc. Natl. Acad. Sci. USA 85, 6612 (1988).
2, Schneider J, and Kent SBH. Cell 54, 363 (1988).
3, Gehringer H et al. J. Virol. Methods 109, 143 (2003).
Molecular Weight 2008.1
(One-Letter Code)
QXL® 520-GABA-SQNYPIVQ-K(HiLyte™ Fluor 488)-NH2
(Three-Letter Code)
QXL® 520 - GABA - Ser - Gln - Asn - Tyr - Pro - Ile - Val - Gln - Lys(Hilyte™ Fluor 488) - NH2
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